GLP-1 Weight Loss Treatment

Clinically supervised
weight loss, delivered.

Compounded semaglutide and tirzepatide. Licensed providers. Ships to your door in all 50 states.

Starting at $249/month. Prescription required. Results may vary.

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🏥 Licensed Medical Providers
💊 FDA-Registered Compounding Pharmacy
🗺️ All 50 States
🔒 HIPAA Compliant
15,000+
Patients Treated
~15%
Avg. Body Weight Lost*
24 hrs
Provider Review Time
50
States Served
4.8★
Patient Satisfaction

*Average weight loss based on published clinical trial data for the active pharmaceutical ingredient. Individual results will vary. Not a guarantee.

Medications

Two clinically studied options

Both are once-weekly self-injections prescribed by a licensed provider based on your individual health profile.

Compounded injectable medication vials
Option 1

Compounded Semaglutide

A GLP-1 receptor agonist that signals the brain to reduce hunger, slows gastric emptying, and helps regulate blood sugar. Published clinical trial data on the active ingredient showed an average of ~15% body weight reduction at 68 weeks.

Starting at $249/month
  • Once-weekly subcutaneous injection
  • Gradual dose titration (0.25mg → 2.4mg)
  • Provider check-ins included
  • Syringes & supplies included
Learn More
Clinical treatment medications
Option 2

Compounded Tirzepatide

A dual GLP-1/GIP receptor agonist — the more recently approved mechanism. Published clinical trial data on the active ingredient showed an average of up to ~22% body weight reduction at 72 weeks, making it the most effective approved option studied to date.

Starting at $349/month
  • Once-weekly subcutaneous injection
  • Gradual dose titration (2.5mg → 15mg)
  • Provider check-ins included
  • Syringes & supplies included
Learn More
Compounded medications are prepared by state-licensed compounding pharmacies and are not FDA-approved products. Clinical trial data referenced is for the active pharmaceutical ingredient and may not reflect outcomes for compounded formulations. A valid prescription is required.
Simple Process

From intake to doorstep in days

No in-office visit required. Most patients are approved within 24 hours.

1

Complete Online Intake

Answer a 10-minute health questionnaire. No video visit required. Covers medical history, goals, and current medications.

2

Provider Review

A licensed MD or DO at Crafted Rx reviews your intake and determines eligibility — typically within 24 hours on business days.

3

Prescription Dispensed

If approved, your prescription is sent to a state-licensed compounding pharmacy and shipped directly to your address. Arrives in 3–5 business days.

4

Ongoing Support

Monthly check-ins, dose adjustments, and clinical support for as long as you're in treatment.

Healthcare provider reviewing patient information
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Clinical Data

Results backed by
published research

~22%
Average body weight reduction with tirzepatide at 72 weeks
*SURMOUNT-1 trial data (active ingredient)
~15%
Average body weight reduction with semaglutide at 68 weeks
*STEP-1 trial data (active ingredient)
91%
Of participants in published trials achieved clinically meaningful weight loss (>5%)
*Pooled trial data for active ingredient

Clinical trial data is for the FDA-approved active pharmaceutical ingredient. Compounded medications are not FDA-approved and are not equivalent to commercially manufactured drugs. Individual results will vary significantly.

Person achieving weight loss goals

"I've tried everything. This is the first approach that actually worked for me."

— M.K., OriRx patient

Why OriRx

How we compare

OriRx In-Person Clinic Brand-Name Rx
Prescription required✓ Yes✓ Yes✓ Yes
Licensed medical provider✓ Yes✓ Yes✓ Yes
Online intake (no office visit)✓ Yes✗ No✗ Varies
Ships to your door✓ Yes✗ No✗ Varies
All 50 states✓ Yes✗ Limited✗ Varies
Starting price$249/mo$400–$800/mo$900–$1,500/mo*
FDA-approved product✗ CompoundedVaries✓ Yes

*Brand-name pricing without insurance and without manufacturer coupons. Compounded medications are not FDA-approved. They are not equivalent to commercially manufactured brand-name drugs.

Patient Stories

Real people, real results

Individual results vary. These are uncompensated patient accounts.

★★★★★

After years of struggling, my provider approved me within a day. The whole process was so much easier than I expected — and I've lost 28 pounds in four months. The monthly check-ins keep me accountable.

Patient
Sandra M.
Lost 28 lbs in 4 months · Texas
★★★★★

I was skeptical about doing this online but the process was genuinely clinical and thorough. My provider asked detailed follow-up questions before prescribing. I felt like I was actually being cared for, not just sold something.

Patient
David R.
Down 19 lbs · Florida
★★★★★

The nausea the first few weeks was real, but my provider adjusted my dose and it got much better. I'm 22 lbs down in three months. The price is a fraction of what my endocrinologist quoted me for the same medication.

Patient
Jennifer K.
Lost 22 lbs in 3 months · California

Results are individual patient accounts and are not typical. Individual results will vary. These testimonials are not a guarantee of outcome.

Built on Trust

The clinical backbone that makes it work

⚕️

Licensed Prescribers

All prescriptions are issued by licensed MDs and DOs at Crafted Rx — our prescriber partner — licensed to practice in all 50 states. No prescriptions from OriRx itself.

Meet our prescribers →
🏭

State-Licensed Compounding Pharmacy

Medications are prepared and dispensed by a state-licensed compounding pharmacy operating under USP 797/800 standards. Not FDA-approved — see our full medication disclosure.

Medication info →
🔒

HIPAA-Compliant Platform

Your health information is handled under HIPAA privacy and security rules. Encrypted storage, strict access controls, and a published Notice of Privacy Practices.

HIPAA notice →
FAQ

Common questions

Am I eligible for treatment? +

You may qualify if your BMI is 30 or higher, or 27 or higher with a weight-related condition (type 2 diabetes, high blood pressure, high cholesterol, or sleep apnea). Final eligibility is determined exclusively by your prescribing provider at Crafted Rx.

What's actually included in the monthly price? +

Everything. Provider consultation, prescription management, the compounded medication, syringes, and standard shipping. No hidden fees. The price you see is the price you pay.

Is a prescription required? +

Yes, always. OriRx facilitates the connection between patients and licensed prescribers. No medication ships without a valid prescription from a licensed provider who has independently reviewed your intake.

What's the difference between compounded and brand-name? +

Compounded medications use the same active pharmaceutical ingredient but are prepared by a compounding pharmacy rather than manufactured commercially. Compounded medications are not FDA-approved and are not identical to brand-name drugs. They cost significantly less because they bypass the commercial manufacturing chain.

How long until I see results? +

Most patients notice appetite reduction within the first 2–4 weeks. Meaningful weight loss typically becomes visible by week 8–12 as the dose increases. Published clinical trials ran 68–72 weeks. Weight loss is a process — not a quick fix.

Can I cancel anytime? +

Yes. Cancel anytime by emailing support@orirx.com. You'll retain access through the end of your current billing period. No cancellation fees. Your provider will guide you on appropriate tapering if you decide to stop medication.

Get Started

Ready to start your weight loss journey?

Complete your health intake in under 10 minutes. Provider review within 24 hours. Prescription required.

Start Your Free Intake

No commitment. Cancel anytime. Prescription at provider's discretion.